#3932 INSULIN RESISTANCE IN PEDIATRIC CKD PATIENTS
نویسندگان
چکیده
Abstract Background and Aims Pediatric chronic kidney disease (CKD) is associated with disturbance of glucose metabolism & insulin receptor sensitivity leading to impaired tolerance resistance (IR), which are potential risk factors for cardiovascular (CVD). Hyperinsulinemia IR not extensively investigated in children CKD, especially different stages CKD. The aim our study was detect hyperinsulinemia pediatric CKD patients. Method A total 87 adolescents; 58 (CKD); (29 stage 2-4, pre-dialysis group 29 5 on regular hemodialysis, CKD5d group) age gender matched controls were enrolled the current cross-sectional study. Homeostasis model assessment (HOMA-IR) using fasting glucose, where considered if HOMA-IR 4.39. Results Fasting hadn't significantly changed between patients (p = 0.7, 0.3 respectively), while represented by found a 11 (12.6%) (6, 6.89% 5, 5.74% 2-4) no significant difference dialysis groups (p>0.05), it 0.039), meanwhile, means statistically all 0.64). correlated positively durations <0.001, <0.001 but BMI. Conclusion Pre-dialysis at high hence CVD. independent IR.
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2023
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfad063c_3932